Decoding cellular mechanism of recombinant adeno-associated virus (rAAV) and engineering host-cell factories toward intensified viral vector manufacturing
Recombinant adeno-associated virus (rAAV) is one of the prominent gene delivery vehicles
that has opened promising opportunities for novel gene therapeutic approaches. However …
that has opened promising opportunities for novel gene therapeutic approaches. However …
[HTML][HTML] Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms
Recombinant adeno-associated viruses (rAAVs) stand at the forefront of gene therapy
applications, holding immense significance for their safe and efficient gene delivery …
applications, holding immense significance for their safe and efficient gene delivery …
The downstream bioprocess toolbox for therapeutic viral vectors
Viral vectors are poised to acquire a prominent position in modern medicine and
biotechnology owing to their role as delivery agents for gene therapies, oncolytic agents …
biotechnology owing to their role as delivery agents for gene therapies, oncolytic agents …
High‐yield recombinant adeno‐associated viral vector production by multivariate optimization of bioprocess and transfection conditions
Recombinant adeno‐associated viral vectors (rAAVs) are one of the most used vehicles for
gene therapy, with five rAAV therapeutics commercially approved by the FDA. To improve …
gene therapy, with five rAAV therapeutics commercially approved by the FDA. To improve …
Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells
The recombinant adeno-associated virus (rAAV) vector is among the most promising viral
vectors in gene therapy. However, the limited manufacturing capacity in human embryonic …
vectors in gene therapy. However, the limited manufacturing capacity in human embryonic …
HEK-omics: The promise of omics to optimize HEK293 for recombinant adeno-associated virus (rAAV) gene therapy manufacturing
SGR Gurazada, HM Kennedy, RD Braatz… - Biotechnology …, 2024 - Elsevier
Gene therapy is poised to transition from niche to mainstream medicine, with recombinant
adeno-associated virus (rAAV) as the vector of choice. However, robust, scalable …
adeno-associated virus (rAAV) as the vector of choice. However, robust, scalable …
Miniaturization of hiPSC-derived 3D neural cultures in stirred-tank bioreactors for parallelized preclinical assessment of rAAV
CM Gomes, MJ Sebastião, G Silva, F Moura… - … in Bioengineering and …, 2024 - frontiersin.org
Introduction: Engineered 3D models employing human induced pluripotent stem cell
(hiPSC) derivatives have the potential to recapitulate the cell diversity and structure found in …
(hiPSC) derivatives have the potential to recapitulate the cell diversity and structure found in …
Challenges and Solutions in the Recombinant Expression of Membrane Proteins
C Liu, H He, J Tian, Y Ma - Protein and Peptide Letters, 2023 - benthamdirect.com
Membrane proteins are important components of the proteome and play key roles in many
biological processes, such as signal transduction, material transport, cell recognition, etc …
biological processes, such as signal transduction, material transport, cell recognition, etc …
Accelerated Development of AAV Purification Process Using a High-Throughput and Automated Crossflow System
S Mendes, TQ Faria, A Nascimento, M Noverraz… - Separations, 2024 - mdpi.com
Adeno-associated viruses (AAV) are currently predominant viral transfer tools for gene
therapy, and efforts are being made to design faster and more efficient methods and …
therapy, and efforts are being made to design faster and more efficient methods and …
[引用][C] Advanced cell technologies: Making protein, cell, and gene therapies a reality
I Geada, A Roldão, MJ Betenbaugh… - Biotechnology and …, 2023 - Wiley Online Library
Researchers and engineers came together in Lisbon at the 27th Meeting of the European
Society for Animal Cell Technology (ESACT 2022), to discuss the latest advances in …
Society for Animal Cell Technology (ESACT 2022), to discuss the latest advances in …