Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Objective This review will focus on the immunological aspects of adipose tissue and its
potential role in development of chronic inflammation that instigates obesity‐associated …

Interactions between macrophages and adipocytes influence both metabolism and
inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic …

Obesity and associated chronic inflammation initiate a state of insulin resistance (IR). The
secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α, and IL …

Ageing, like obesity, is often associated with alterations in metabolic and inflammatory
processes resulting in morbidity from diseases characterised by poor metabolic control …

Aims/hypothesis A high-fat dietary intake induces obesity and subclinical inflammation,
which play important roles in insulin resistance. Recent studies have suggested that …

During obesity, macrophage accumulation in adipose tissue propagates the chronic
inflammation and insulin resistance associated with type 2 diabetes. The factors, however …