Low-grade gliomas (LGGs) are a diverse group of primary brain tumors that often arise in
young, otherwise healthy patients and generally have an indolent course with longer-term …

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53,
playing a key role in controlling its transcriptional activity, protein stability, and nuclear …

Abstract The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse
gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel …

Context There are no controlled studies on surgical treatment of diffuse low-grade gliomas
(LGGs), and management is controversial. Objective To examine survival in population …

OBJECTIVE: It remains unknown whether the extent of surgical resection affects survival or
disease progression in patients with supratentorial low-grade gliomas. METHODS: We …

Object Accurate discrimination between tumor and normal tissue is crucial for optimal tumor
resection. Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously …

BACKGROUND Awake craniotomy with intraoperative electrical mapping is a reliable
method to minimize the risk of permanent deficit during surgery for low-grade glioma located …

Diffuse low grade gliomas (DLGG) are continuously progressive primary brain neoplasms
that lead to neurological deficits and death. Treatment strategies are controversial …

Simple Summary Diffuse low-grade gliomas (LGG) are relatively uncommon primary brain
cancers. In recent years, the molecular, diagnostic, and therapeutic approaches have …

Background: Imaging determinations of the spatial extent of diffuse low-grade gliomas
(DLGGs) are of paramount importance in evaluating the risk-to-benefit ratio of surgical …