Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Hydrogen sulfide biochemistry and interplay with other gaseous mediators in mammalian physiology

A Giuffrè, JB Vicente - Oxidative medicine and cellular longevity, 2018 - Wiley Online Library
Hydrogen sulfide (H2S) has emerged as a relevant signaling molecule in physiology, taking
its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO) …

Toward hydrogen sulfide based therapeutics: critical drug delivery and developability issues

Y Zheng, B Yu, LK De La Cruz… - Medicinal Research …, 2018 - Wiley Online Library
Abstract Hydrogen sulfide (H2S), together with nitric oxide (NO) and carbon monoxide (CO),
belongs to the gasotransmitter family and plays important roles in mammals as a signaling …

Hydrogen sulfide in pharmacology and medicine–an update

J Bełtowski - Pharmacological Reports, 2015 - Elsevier
Hydrogen sulfide (H 2 S) is the endogenously produced gasotransmitter involved in the
regulation of nervous system, cardiovascular functions, inflammatory response …

Inhibition of succinate dehydrogenase by pesticides (SDHIs) and energy metabolism

F Bouillaud - International Journal of Molecular Sciences, 2023 - mdpi.com
Succinate dehydrogenase (SDH) is one of the enzymes of the tricarboxylic acid cycle (Krebs
cycle) and complex II of the mitochondrial respiratory chain. A class of fungicides (SDHIs) …

Hydrogen sulfide signaling: interactions with nitric oxide and reactive oxygen species

JT Hancock, M Whiteman - Annals of the New York Academy of …, 2016 - Wiley Online Library
Signaling in cells involving reactive compounds is well established. Reactive oxygen
species (ROS) and nitric oxide (NO) are known to be extremely influential in the control of a …

Mechanistic chemical perspective of hydrogen sulfide signaling

P Nagy - Methods in enzymology, 2015 - Elsevier
Hydrogen sulfide is now a well-appreciated master regulator in a diverse array of
physiological processes. However, as a consequence of the rapid growth of the area, sulfide …

Hydrogen sulfide: a versatile regulator of environmental stress in plants

H Guo, T Xiao, H Zhou, Y Xie, W Shen - Acta Physiologiae Plantarum, 2016 - Springer
In mammalian cells, hydrogen sulfide (H 2 S) has been identified as the third gasotransmitter
after nitric oxide and carbon monoxide. Overwhelming evidence has proven that H 2 S also …

Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia …

C Coletta, K Módis, B Szczesny, A Brunyánszki… - Molecular …, 2015 - Springer
Abstract Hydrogen sulfide (H 2 S), as a reducing agent and an antioxidant molecule, exerts
protective effects against hyperglycemic stress in the vascular endothelium. The …

Ratiometric Detection of H2S in Liver Injury by Activated Two-Wavelength Photoacoustic Imaging

R Wu, Z Chen, H Huo, L Chen, L Su, X Zhang… - Analytical …, 2022 - ACS Publications
Metformin is commonly used for clinical treatment of type-2 diabetes, but long-term or
overdose intake of metformin usually causes selective upregulation of H2S level in the liver …