Possibilities and challenges for developing a successful vaccine for leishmaniasis
Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …
Vaccines for visceral leishmaniasis: A review
K Jain, NK Jain - Journal of immunological methods, 2015 - Elsevier
Visceral leishmaniasis, which is also known as Kala-Azar, is one of the most severely
neglected tropical diseases recognized by the World Health Organization (WHO). The threat …
neglected tropical diseases recognized by the World Health Organization (WHO). The threat …
From infection to vaccination: reviewing the global burden, history of vaccine development, and recurring challenges in global leishmaniasis protection
G Volpedo, RH Huston, EA Holcomb… - Expert review of …, 2021 - Taylor & Francis
Introduction Leishmaniasis is a major public health problem and the second most lethal
parasitic disease in the world due to the lack of effective treatments and vaccines. Even …
parasitic disease in the world due to the lack of effective treatments and vaccines. Even …
Vaccine candidates against leishmania under current research
Introduction: The search for vaccines to prevent human leishmaniasis is an active field of
investigation aimed to prevent the devastating effects of this family of diseases on human …
investigation aimed to prevent the devastating effects of this family of diseases on human …
Host–pathogen interaction in leishmaniasis: immune response and vaccination strategies
Leishmaniasis is a zoonotic and vector-borne infectious disease that is caused by the genus
Leishmania belonging to the trypanosomatid family. The protozoan parasite has a digenetic …
Leishmania belonging to the trypanosomatid family. The protozoan parasite has a digenetic …
Immunoinformatics Approach to Design a Multi-Epitope Nanovaccine against Leishmania Parasite: Elicitation of Cellular Immune Responses
Leishmaniasis is a vector-borne disease caused by an intracellular parasite of the genus
Leishmania with different clinical manifestations that affect millions of people worldwide …
Leishmania with different clinical manifestations that affect millions of people worldwide …
The History of Live Attenuated Centrin Gene-Deleted Leishmania Vaccine Candidates
Leishmaniasis, caused by an infection of the Leishmania protozoa, is a neglected tropical
disease and a major health problem in tropical and subtropical regions of the world, with …
disease and a major health problem in tropical and subtropical regions of the world, with …
Role of pro-inflammatory cytokine IL-17 in Leishmania pathogenesis and in protective immunity by Leishmania vaccines
A Banerjee, P Bhattacharya, AB Joshi, N Ismail… - Cellular …, 2016 - Elsevier
The clinical outcome of Leishmania pathogenesis ranges from active skin lesions to fatal
visceral dissemination and severely impaired T cell immunity. It is well established that a …
visceral dissemination and severely impaired T cell immunity. It is well established that a …
Next-Generation Leishmanization: Revisiting Molecular Targets for Selecting Genetically Engineered Live-Attenuated Leishmania
POL Moreira, PM Nogueira, RL Monte-Neto - Microorganisms, 2023 - mdpi.com
Despite decades of research devoted to finding a vaccine against leishmaniasis, we are still
lacking a safe and effective vaccine for humans. Given this scenario, the search for a new …
lacking a safe and effective vaccine for humans. Given this scenario, the search for a new …
Visceral leishmaniasis: advancements in vaccine development via classical and molecular approaches
Visceral leishmaniasis (VL) or kala-azar, a vector-borne protozoan disease, shows
endemicity in larger areas of the tropical, subtropical and the Mediterranean countries. WHO …
endemicity in larger areas of the tropical, subtropical and the Mediterranean countries. WHO …