Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts
D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …
damage and their management by repair mechanisms. However, molecular biology studies …
Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications
AS Manolis, AA Manolis, TA Manolis… - Medicinal Research …, 2021 - Wiley Online Library
Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …
Ionizing radiation-induced brain cell aging and the potential underlying molecular mechanisms
QQ Wang, G Yin, JR Huang, SJ Xi, F Qian, RX Lee… - Cells, 2021 - mdpi.com
Population aging is occurring rapidly worldwide, challenging the global economy and
healthcare services. Brain aging is a significant contributor to various age-related …
healthcare services. Brain aging is a significant contributor to various age-related …
Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside
Cancer management has undergone significant improvements, which led to increased long-
term survival rates among cancer patients. Radiotherapy (RT) has an important role in the …
term survival rates among cancer patients. Radiotherapy (RT) has an important role in the …
The senescence-associated secretory phenotype: Fueling a wound that never heals
T Pulido, MC Velarde, F Alimirah - Mechanisms of Ageing and …, 2021 - Elsevier
Wound healing is impaired with advanced age and certain chronic conditions, such as
diabetes and obesity. Moreover, common cancer treatments, including chemotherapy and …
diabetes and obesity. Moreover, common cancer treatments, including chemotherapy and …
Cardiac inflammation and fibrosis following chemo/radiation therapy: mechanisms and therapeutic agents
The incidence of cardiovascular disorders is one of the most concerns among people who
underwent cancer therapy. The heart side effects of cancer therapy may occur during …
underwent cancer therapy. The heart side effects of cancer therapy may occur during …
Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease
O Azimzadeh, S Moertl, R Ramadan… - … Journal of Radiation …, 2022 - Taylor & Francis
Background Epidemiological studies have indicated that exposure of the heart to doses of
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …
[HTML][HTML] A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus
N Melin, T Yarahmadov, D Sanchez-Taltavull, FE Birrer… - JHEP reports, 2022 - Elsevier
Background & Aims High-dose irradiation is an essential tool to help control the growth of
hepatic tumors, but it can cause radiation-induced liver disease (RILD). This life-threatening …
hepatic tumors, but it can cause radiation-induced liver disease (RILD). This life-threatening …
[HTML][HTML] Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy
JA Nickoloff, L Taylor, N Sharma… - Cancer Drug Resistance, 2021 - ncbi.nlm.nih.gov
More than half of cancer patients are treated with radiotherapy, which kills tumor cells by
directly and indirectly inducing DNA damage, including cytotoxic DNA double-strand breaks …
directly and indirectly inducing DNA damage, including cytotoxic DNA double-strand breaks …
Early Changes in Rat Heart After High‐Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation
MJ Cha, JW Seo, HJ Kim, M Kim, H Yoon… - Journal of the …, 2021 - Am Heart Assoc
Background Noninvasive cardiac radioablation is employed to treat ventricular arrhythmia.
However, myocardial changes leading to early‐period antiarrhythmic effects induced by …
However, myocardial changes leading to early‐period antiarrhythmic effects induced by …