Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts

D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications

AS Manolis, AA Manolis, TA Manolis… - Medicinal Research …, 2021 - Wiley Online Library
Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …

Ionizing radiation-induced brain cell aging and the potential underlying molecular mechanisms

QQ Wang, G Yin, JR Huang, SJ Xi, F Qian, RX Lee… - Cells, 2021 - mdpi.com
Population aging is occurring rapidly worldwide, challenging the global economy and
healthcare services. Brain aging is a significant contributor to various age-related …

Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside

M Sárközy, Z Varga, R Gáspár, G Szűcs… - Clinical Research in …, 2021 - Springer
Cancer management has undergone significant improvements, which led to increased long-
term survival rates among cancer patients. Radiotherapy (RT) has an important role in the …

The senescence-associated secretory phenotype: Fueling a wound that never heals

T Pulido, MC Velarde, F Alimirah - Mechanisms of Ageing and …, 2021 - Elsevier
Wound healing is impaired with advanced age and certain chronic conditions, such as
diabetes and obesity. Moreover, common cancer treatments, including chemotherapy and …

Cardiac inflammation and fibrosis following chemo/radiation therapy: mechanisms and therapeutic agents

R Yang, C Tan, M Najafi - Inflammopharmacology, 2022 - Springer
The incidence of cardiovascular disorders is one of the most concerns among people who
underwent cancer therapy. The heart side effects of cancer therapy may occur during …

Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease

O Azimzadeh, S Moertl, R Ramadan… - … Journal of Radiation …, 2022 - Taylor & Francis
Background Epidemiological studies have indicated that exposure of the heart to doses of
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …

[HTML][HTML] A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus

N Melin, T Yarahmadov, D Sanchez-Taltavull, FE Birrer… - JHEP reports, 2022 - Elsevier
Background & Aims High-dose irradiation is an essential tool to help control the growth of
hepatic tumors, but it can cause radiation-induced liver disease (RILD). This life-threatening …

[HTML][HTML] Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy

JA Nickoloff, L Taylor, N Sharma… - Cancer Drug Resistance, 2021 - ncbi.nlm.nih.gov
More than half of cancer patients are treated with radiotherapy, which kills tumor cells by
directly and indirectly inducing DNA damage, including cytotoxic DNA double-strand breaks …

Early Changes in Rat Heart After High‐Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation

MJ Cha, JW Seo, HJ Kim, M Kim, H Yoon… - Journal of the …, 2021 - Am Heart Assoc
Background Noninvasive cardiac radioablation is employed to treat ventricular arrhythmia.
However, myocardial changes leading to early‐period antiarrhythmic effects induced by …