Cancer cells must rewire cellular metabolism to satisfy the demands of growth and
proliferation. Although many of the metabolic alterations are largely similar to those in …

Renal ammonia metabolism and transport mediates a central role in acid-base homeostasis.
In contrast to most renal solutes, the majority of renal ammonia excretion derives from …

The most common malignant brain tumors are those of astrocytic origin, gliomas, with the
most aggressive glioblastoma (WHO grade IV) among them. Despite efforts, medicine has …

The metabolic adaptations that support oncogenic growth can also render cancer cells
dependent on certain nutrients. Along with the Warburg effect, increased utilization of …

Mitochondrial glutaminase (GA) plays an essential role in cancer cell metabolism,
contributing to biosynthesis, bioenergetics, and redox balance. Humans contain several GA …

Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of
metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine …

Glutamine is a multifaceted amino acid that plays key roles in many metabolic pathways and
also fulfils essential signaling functions. Although classified as non-essential, recent …

Triple-negative breast cancers (TNBCs) lack progesterone and estrogen receptors and do
not have amplified human epidermal growth factor receptor 2, the main therapeutic targets …

Phosphate-activated mitochondrial glutaminase (GLS2) is suggested to be linked with
elevated glutamine metabolism. It plays an important role in catalyzing the hydrolysis of …

Cancer cells develop and succeed by shifting to different metabolic programs compared with
their normal cell counterparts. One of the classical hallmarks of cancer cells is their higher …