Cardiac contractility is regulated by several neural, hormonal, paracrine, and autocrine
factors. Amongst these, signaling through β-adrenergic and serotonin receptors generates …

Activation of different receptors that act by generating the common second messenger cyclic
adenosine monophosphate (cAMP) can elicit distinct functional responses in cardiac …

Hydroxycholesterol (25HC) is a biologically active oxysterol, whose production greatly
increases during inflammation by macrophages and dendritic cells. The inflammatory …

BACKGROUND: In heart failure, signaling downstream the β2-adrenergic receptor is critical.
Sympathetic stimulation of β2-adrenergic receptor alters cAMP (cyclic adenosine 3′, 5 …

Background: β1AR (beta-1 adrenergic receptor) and β2AR (beta-2 adrenergic receptor)-
mediated cyclic adenosine monophosphate signaling has distinct effects on cardiac function …

Compartmentation of cAMP signaling is a critical factor for maintaining the integrity of
receptor‐specific responses in cardiac myocytes. This phenomenon relies on various factors …

The small diffusible second messenger 3′, 5′‐cyclic adenosine monophosphate (cAMP)
is found in virtually every cell in our bodies, where it mediates responses to a variety of …

Dilated cardiomyopathies (DCM) represent a diverse group of cardiovascular diseases
impacting the structure and function of the myocardium. To better treat these diseases, we …

Cardiovascular failure is the main cause of death in industrialized societies. The results of
recent studies have shown that some mutations in the MEFV gene are common in heart …

3′, 5′-Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger
which plays critical roles in cardiac function and disease. In adult mouse ventricular …