Current standard-of-care (SOC) therapy for breast cancer includes targeted therapies such
as endocrine therapy for estrogen receptor-alpha (ERα) positive; anti-HER2 monoclonal …

Amino acid transporters are membrane transport proteins, most of which are members of the
solute carrier families. Amino acids are essential for the survival of all types of cells …

How tumor cells genetically lose antigenicity and evade immune checkpoints remains
largely elusive. We report that tissue-specific expression of the human long noncoding RNA …

Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic
enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated …

African American (AA) women in the United States have a 40% higher breast cancer
mortality rate than Non-Hispanic White (NHW) women. The survival disparity is particularly …

Background Among breast cancers, the triple-negative breast cancer (TNBC) subtype has
the worst prognosis with no approved targeted therapies and only standard chemotherapy …

Breast cancer (BC) is a heterogeneous disease which has been characterised and stratified
by many platforms such as clinicopathological risk factors, genomic assays, computer …

Cancer treatment options are increasing. However, even among the same tumor histotype,
interpatient tumor heterogeneity should be considered for best therapeutic result …

Among breast cancer subtypes, the triple negative breast cancer (TNBC) has the worst
prognosis. In absence of any permitted targeted therapy, standard chemotherapy is the …

Breast cancer is the most commonly diagnosed cancer in women worldwide. Major
advances have been made towards breast cancer prevention and treatment. Unfortunately …