Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which
maintain lung homeostasis through their dual roles as anti-infectious and …

Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

Pseudomonas aeruginosa is an important pathogen causing a wide range of acute and
chronic infections. P. aeruginosa rarely causes infection in the normal host, but is an efficient …

Lipidomics, after genomics and proteomics, is a newly and rapidly expanding research field
that studies cellular lipidomes and the organizational hierarchy of lipid and protein …

Neutrophil extracellular traps (NETs) are beneficial antimicrobial defense structures that can
help fight against invading pathogens in the host. However, recent studies reveal that NETs …

Lipopolysccharide (LPS) is an integral component of the Pseudomonas aeruginosa cell
envelope, occupying the outer leaflet of the outer membrane in this Gram-negative …

▪ Abstract The lung collectins, SP-A and SP-D, are important components of the innate
immune response to microbial challenge and participate in other aspects of immune and …

Cystic fibrosis is characterized by an early and sustained influx of inflammatory cells into the
airways and by release of proteases. Resolution of inflammation is normally associated with …

The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), have been reported to
bind lipopolysaccharide (LPS), opsonize microorganisms, and enhance the clearance of …

Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, whereas chronic
obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly …