The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …

The MAP kinase (MAPK) signalling pathways play fundamental roles in a wide range of
cellular processes and are often deregulated in disease states. One major mode of action for …

Precise gene expression ensures proper stem and progenitor cell differentiation, lineage
commitment and organogenesis during mammalian development. ATP-dependent …

Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury
in the adult constitutes an excellent paradigm to investigate the mechanisms whereby …

Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also
known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report …

Somatic mutations accumulate in all cells with age and can confer a selective advantage,
leading to clonal expansion over time. In hematopoietic cells, mutations in a subset of genes …

In response to muscle injury, muscle stem cells integrate environmental cues in the
damaged tissue to mediate regeneration. These environmental cues are tightly regulated to …

Skeletal muscle development and regeneration is governed by the combined action of Myf5,
MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These …

Light is a key environmental cue that fundamentally regulates plant growth and
development, which is mediated by the multiple photoreceptors including the blue light (BL) …

Deposition of the histone variant H2A. Z at gene bodies regulates transcription by modifying
chromatin accessibility in plants. However, the role of H2A. Z enrichment at the promoter and …