Background Worldwide, many people suffer from knee injuries and articular cartilage
damage every year, which causes pain and reduces productivity, life quality, and daily …

The use of tissue-engineered articular cartilage (TEAC) constructs has the potential to
become a powerful treatment option for cartilage lesions resulting from trauma or early …

This review paper explores the cutting-edge advancements in hydrogel design for articular
cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence …

The ex vivo engineering of autologous cartilage tissues has the potential to revolutionize the
clinical management of joint disorders. Yet, high manufacturing costs and variable outcomes …

The aim of osteochondral tissue engineering is to achieve the complex, functional and three-
dimensional tissue regeneration under well defined, controlled and reproducible conditions …

Cartilage engineering has the potential to overcome clinical deficiency in joint disorders.
Decellularized extracellular matrix (dECM) has great biocompatibility and bioactivity and can …

It is well known that the biomechanical and tribological performance of articular cartilage is
inextricably linked to its extracellular matrix (ECM) structure and zonal heterogeneity …

Untreated osteochondral defects are a leading cause of osteoarthritis, a condition that
places a heavy burden on both patients and orthopedic surgeons. Although tissue …

Chondrocytes that are impregnated within hydrogel constructs sense applied mechanical
force and can respond by expressing collagens, which are deposited into the extracellular …

Mechanical metamaterials are rationally designed structures engineered to exhibit
extraordinary properties, often surpassing those of their constituent materials. The geometry …