Integrative omics approaches for biosynthetic pathway discovery in plants
Covering: up to 2022 With the emergence of large amounts of omics data, computational
approaches for the identification of plant natural product biosynthetic pathways and their …
approaches for the identification of plant natural product biosynthetic pathways and their …
A century of studying plant secondary metabolism—from “what?” to “where, how, and why?”
RA Dixon, AJ Dickinson - Plant Physiology, 2024 - academic.oup.com
Over the past century, early advances in understanding the identity of the chemicals that
collectively form a living plant have led scientists to deeper investigations exploring where …
collectively form a living plant have led scientists to deeper investigations exploring where …
Oxetane ring formation in taxol biosynthesis is catalyzed by a bifunctional cytochrome P450 enzyme
Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted
extensive research into its biosynthesis. However, certain critical steps, such as the …
extensive research into its biosynthesis. However, certain critical steps, such as the …
Biosynthesis and biotechnological production of the anti-obesity agent celastrol
Y Zhao, NL Hansen, YT Duan, M Prasad… - Nature Chemistry, 2023 - nature.com
Obesity is a major health risk still lacking effective pharmacological treatment. A potent anti-
obesity agent, celastrol, has been identified in the roots of Tripterygium wilfordii. However …
obesity agent, celastrol, has been identified in the roots of Tripterygium wilfordii. However …
Insights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants
HT Wang, ZL Wang, K Chen, MJ Yao, M Zhang… - Nature …, 2023 - nature.com
Apiose is a natural pentose containing an unusual branched-chain structure. Apiosides are
bioactive natural products widely present in the plant kingdom. However, little is known on …
bioactive natural products widely present in the plant kingdom. However, little is known on …
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria
X Shi, G Zhao, H Li, Z Zhao, W Li, M Wu… - Nature Chemical …, 2023 - nature.com
Hydroxytryptophan serves as a chemical precursor to a variety of bioactive specialized
metabolites, including the human neurotransmitter serotonin and the hormone melatonin …
metabolites, including the human neurotransmitter serotonin and the hormone melatonin …
The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids
EA Stander, B Lehka, I Carqueijeiro, C Cuello… - Communications …, 2023 - nature.com
Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized
metabolites mainly produced in Gentianales to cope with environmental challenges. Due to …
metabolites mainly produced in Gentianales to cope with environmental challenges. Due to …
[HTML][HTML] Engineering Nicotiana benthamiana as a platform for natural product biosynthesis
Nicotiana benthamiana is a model plant, widely used for research. The susceptibility of
young plants to Agrobacterium tumefaciens has been utilised for transient gene expression …
young plants to Agrobacterium tumefaciens has been utilised for transient gene expression …
Using Synthetic Biology to Understand the Function of Plant Specialized Metabolites
Y Bai, X Liu, IT Baldwin - Annual Review of Plant Biology, 2024 - annualreviews.org
Plant specialized metabolites (PSMs) are variably distributed across taxa, tissues, and
ecological contexts; this variability has inspired many theories about PSM function, which to …
ecological contexts; this variability has inspired many theories about PSM function, which to …
Proteomics-Guided Mining and Characterization of Epoxidase Involved in Camptothecin Biosynthesis from Camptotheca acuminata
X Pu, M Wang, M Chen, X Lin, M Lei… - ACS Chemical …, 2023 - ACS Publications
The detailed metabolic map for camptothecin (CPT) biosynthesis in Camptotheca acuminata
has been proposed according to our combined omics results. However, the CYP450 …
has been proposed according to our combined omics results. However, the CYP450 …