Cytokines: from clinical significance to quantification
Cytokines are critical mediators that oversee and regulate immune and inflammatory
responses via complex networks and serve as biomarkers for many diseases. Quantification …
responses via complex networks and serve as biomarkers for many diseases. Quantification …
[HTML][HTML] Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines
A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …
Sepsis: pathophysiology and clinical management
JE Gotts, MA Matthay - Bmj, 2016 - bmj.com
Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …
inflammatory responses to infection. Sepsis is common in the aging population, and it …
Immunotherapeutic implications of IL-6 blockade for cytokine storm
T Tanaka, M Narazaki, T Kishimoto - Immunotherapy, 2016 - Future Medicine
IL-6 contributes to host defense against infections and tissue injuries. However,
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …
[HTML][HTML] Sepsis: inflammation is a necessary evil
Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies
available other than ICU treatment. The patient outcome is determined by a complex …
available other than ICU treatment. The patient outcome is determined by a complex …
[HTML][HTML] Interleukin 8 elicits rapid physiological changes in neutrophils that are altered by inflammatory conditions
S Bernhard, S Hug, AEP Stratmann, M Erber… - Journal of innate …, 2021 - karger.com
A sufficient response of neutrophil granulocytes stimulated by interleukin (IL)-8 is vital during
systemic inflammation, for example, in sepsis or severe trauma. Moreover, IL-8 is clinically …
systemic inflammation, for example, in sepsis or severe trauma. Moreover, IL-8 is clinically …
[HTML][HTML] Inflammation and cell death of the innate and adaptive immune system during sepsis
C Nedeva - Biomolecules, 2021 - mdpi.com
Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …
or abnormal immune response to overwhelming infection. It is now widely accepted that …
More than an anticoagulant: Do heparins have direct anti-inflammatory effects?
TJ Poterucha, P Libby… - Thrombosis and …, 2017 - thieme-connect.com
The heparins, well-known for their anticoagulant properties, may also have anti-
inflammatory effects that could contribute to their effectiveness in the treatment of venous …
inflammatory effects that could contribute to their effectiveness in the treatment of venous …
Dynamic balance of pro‐and anti‐inflammatory signals controls disease and limits pathology
Immune responses to pathogens are complex and not well understood in many diseases,
and this is especially true for infections by persistent pathogens. One mechanism that allows …
and this is especially true for infections by persistent pathogens. One mechanism that allows …