[HTML][HTML] The roles of miRNA, lncRNA and circRNA in the development of osteoporosis

Y Yang, W Yujiao, W Fang, Y Linhui, G Ziqi… - Biological …, 2020 - SciELO Chile
Osteoporosis is a common metabolic bone disease, influenced by genetic and
environmental factors, that increases bone fragility and fracture risk and, therefore, has a …

[HTML][HTML] Long non-coding RNAs: from disease code to drug role

Y Chen, Z Li, X Chen, S Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively
participate in crucial physiological processes such as metabolism and immunity, and are …

A road map for understanding molecular and genetic determinants of osteoporosis

TL Yang, H Shen, A Liu, SS Dong, L Zhang… - Nature Reviews …, 2020 - nature.com
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

[HTML][HTML] Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

M Al-Azab, M Safi, E Idiiatullina, F Al-Shaebi… - Cellular & Molecular …, 2022 - Springer
Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

Emerging nano-scale delivery systems for the treatment of osteoporosis

AP Dayanandan, WJ Cho, H Kang, AB Bello… - Biomaterials …, 2023 - spj.science.org
Osteoporosis is a pathological condition characterized by an accelerated bone resorption
rate, resulting in decreased bone density and increased susceptibility to fractures …

[HTML][HTML] m6A methylation of precursor-miR-320/RUNX2 controls osteogenic potential of bone marrow-derived mesenchymal stem cells

G Yan, YE Yuan, M He, R Gong, H Lei, H Zhou… - … Therapy-Nucleic Acids, 2020 - cell.com
Methyltransferase-like 3 (METTL3) is the main enzyme for N 6-methyladenosine (m 6 A)-
based methylation of RNAs and it has been implicated in many biological and …

Bioactive glass nanoparticles inhibit osteoclast differentiation and osteoporotic bone loss by activating lncRNA NRON expression in the extracellular vesicles derived …

Z Yang, X Liu, F Zhao, M Yao, Z Lin, Z Yang, C Liu… - Biomaterials, 2022 - Elsevier
Bioactive glass nanoparticles (BGN) have attracted increasing attention for their use in bone
tissue repair owing to their special osteogenic activity; however, the underlying molecular …

[HTML][HTML] The roles of circRNA–miRNA–mRNA networks in the development and treatment of osteoporosis

M Gao, Z Zhang, J Sun, B Li, Y Li - Frontiers in endocrinology, 2022 - frontiersin.org
Osteoporosis is a systemic metabolic disease, mainly characterized by reduced bone
mineral density and destruction of bone tissue microstructure. However, the molecular …

[HTML][HTML] The roles of epigenetics regulation in bone metabolism and osteoporosis

F Xu, W Li, X Yang, L Na, L Chen, G Liu - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

[HTML][HTML] A functional motif of long noncoding RNA Nron against osteoporosis

F Jin, J Li, YB Zhang, X Liu, M Cai, M Liu, M Li… - Nature …, 2021 - nature.com
Long noncoding RNAs are widely implicated in diverse disease processes. Nonetheless,
their regulatory roles in bone resorption are undefined. Here, we identify lncRNA Nron as a …