Shaping the brain vasculature in development and disease in the single-cell era

T Wälchli, J Bisschop, P Carmeliet, G Zadeh… - Nature Reviews …, 2023 - nature.com
The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Critical roles of protein arginine methylation in the central nervous system

K Chang, D Gao, J Yan, L Lin, T Cui, S Lu - Molecular Neurobiology, 2023 - Springer
A remarkable post-transitional modification of both histones and non-histone proteins is
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …

[HTML][HTML] An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

J Zhou, JM Simon, C Liao, C Zhang, L Hu, G Zurlo… - Molecular cell, 2022 - cell.com
Characterized by intracellular lipid droplet accumulation, clear cell renal cell carcinoma
(ccRCC) is resistant to cytotoxic chemotherapy and is a lethal disease. Through an unbiased …

CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions

M Suzuki, S Sakai, K Ota, Y Bando, C Uchida… - Scientific Reports, 2023 - nature.com
Pairs of sense and antisense transcriptions that are adjacent at their 5′ and 3′ regions are
called divergent and convergent transcription, respectively. However, the structural …

Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

S Cheng, IF Xia, R Wanner, J Abello, AN Stratman… - Elife, 2024 - elifesciences.org
Vascular smooth muscle cells (VSMCs) envelop vertebrate brain arteries and play a crucial
role in regulating cerebral blood flow and neurovascular coupling. The dedifferentiation of …

Serum Interleukin-1 levels are associated with intracranial aneurysm instability

Q Liu, P Liu, Y Zhang, M Mossa-Basha… - Translational Stroke …, 2024 - Springer
Abstract Serum interleukin-1 (IL-1) are possibly indicative of the inflammation in the
intracranial aneurysm (IA) wall. This study aimed to investigate whether IL-1 could …

Systematic identification of post-transcriptional regulatory modules

M Khoroshkin, A Buyan, M Dodel, A Navickas… - Nature …, 2024 - nature.com
In our cells, a limited number of RNA binding proteins (RBPs) are responsible for all aspects
of RNA metabolism across the entire transcriptome. To accomplish this, RBPs form …

A future blood test to detect cerebral aneurysms

KW Nowicki, AM Mittal, H Abou-Al-Shaar… - Cellular and Molecular …, 2023 - Springer
Intracranial aneurysms are reported to affect 2–5% of the population. Despite advances in
the surgical management of this disease, diagnostic technologies have marginally improved …

Influence of humanized nursing on patients with intracranial aneurysm subarachnoid hemorrhage undergoing interventional embolization

G Waili, S Amuti - Heliyon, 2023 - cell.com
Objective To investigate the effect of nursing intervention on patients with intracranial
aneurysm subarachnoid hemorrhage who underwent interventional embolization. Methods …

MicroRNA-451 Regulates Angiogenesis in Intracerebral Hemorrhage by Targeting Macrophage Migration Inhibitory Factor

S Bai, G Zhang, S Chen, X Wu, J Li, J Wang… - Molecular …, 2024 - Springer
Intracerebral hemorrhage (ICH) is a subtype of stroke with the highest fatality and disability
rate. Up to now, commonly used first-line therapies have limited value in improving …