For many decades, experimental solid mechanics has played a crucial role in characterizing
and understanding the mechanical properties of natural and novel artificial materials …

Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …

Cell–cell junctions are specializations of the plasma membrane responsible for physically
integrating cells into tissues. We are now beginning to appreciate the diverse impacts that …

Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core
of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins …

Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their
stability, intrinsic mechanical properties, and cell type–specific expression patterns …

Epithelial and endothelial monolayers are multicellular sheets that form barriers between the
'outside'and 'inside'of tissues. Cell-cell junctions, made by adherens junctions, tight junctions …

The coordinated interplay of cytoskeletal networks critically determines tissue biomechanics
and structural integrity. Here, we show that plectin, a major intermediate filament-based …

Morphological changes during development, tissue repair, and disease largely rely on
coordinated cell movements and are controlled by the tissue environment. Epithelial cell …

Background: Plakophilin-2 (PKP2) is classically defined as a desmosomal protein. Mutations
in PKP2 associate with most cases of gene-positive arrhythmogenic right ventricular …

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …