The molecular chaperone heat shock protein 90 (HSP90) has been used by cancer cells to
facilitate the function of numerous oncoproteins, and it can be argued that cancer cells …

Proteins generally must fold into precise three-dimensional conformations to fulfill their
biological functions. In the cell, this fundamental process is aided by molecular chaperones …

The heat shock protein (HSP90) has been an import target of drug design in the treatment of
human disease. An exploration of the conformational changes in HSP90 can provide useful …

TRAP1, a mitochondrial chaperone (Hsp75) with antioxidant and antiapoptotic functions, is
involved in multidrug resistance in human colorectal carcinoma cells. Through a proteomic …

Given the inherent resistance to apoptosis that characterizes cancer, the targeting of
alternative pathways is an attractive strategy to improve anti-tumor therapy. Endoplasmic …

Wee1 kinase plays an important role in regulating G2/M checkpoint and S phase, and the
inhibition of it will lead to mitotic catastrophe in cancer cells with p53 mutation or deletion …

Attenuated measles virus vaccine strains have emerged as a promising oncolytic vector
platform, having shown significant anti-tumor activity against a broad range of malignant …

The receptor tyrosine kinase ErbB2 is overexpressed in up to a third of breast cancers,
allowing targeted therapy with ErbB2-directed humanized antibodies such as Trastuzumab …

Androgen ablation therapy represents the first line of therapeutic intervention in men with
advanced or recurrent prostate tumors. However, the incomplete efficacy and lack of durable …

Abstract The Human Epidermal Growth Factor Receptor 2 (Her2, ErbB2 or Neu) is
overexpressed in about 20–25% of breast cancers and is causally linked to oncogenesis …