Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

SC Dyall, L Balas, NG Bazan, JT Brenna… - Progress in lipid …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

Specialized pro-resolving mediator network: an update on production and actions

N Chiang, CN Serhan - Essays in Biochemistry, 2020 - portlandpress.com
Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …

Pain-resolving immune mechanisms in neuropathic pain

NT Fiore, SR Debs, JP Hayes, SS Duffy… - Nature Reviews …, 2023 - nature.com
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

M Bäck, A Yurdagul Jr, I Tabas, K Öörni… - Nature Reviews …, 2019 - nature.com
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Low-grade inflammation and ultra-processed foods consumption: a review

M Tristan Asensi, A Napoletano, F Sofi, M Dinu - Nutrients, 2023 - mdpi.com
Low-grade inflammation alters the homeostasis of the organism and favors the onset of
many chronic diseases. The global growth in the prevalence of noncommunicable diseases …

Resolution of inflammation: An organizing principle in biology and medicine

D Panigrahy, MM Gilligan, CN Serhan… - Pharmacology & …, 2021 - Elsevier
The resolution of inflammation has emerged as a critical endogenous process that protects
host tissues from prolonged or excessive inflammation that can become chronic. Failure of …

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

CN Serhan, BD Levy - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Countless times each day, the acute inflammatory response protects us from invading
microbes, injuries, and insults from within, as in surgery-induced tissue injury. These …

Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

D Dobrev, J Heijman, R Hiram, N Li… - Nature Reviews …, 2023 - nature.com
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

[HTML][HTML] Physiology of the endometrium and regulation of menstruation

HOD Critchley, JA Maybin… - Physiological …, 2020 - journals.physiology.org
The physiological functions of the uterine endometrium (uterine lining) are preparation for
implantation, maintenance of pregnancy if implantation occurs, and menstruation in the …

Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function

E Brennan, P Kantharidis, ME Cooper… - Nature Reviews …, 2021 - nature.com
Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …