A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity

G Livshits, A Kalinkovich - Ageing Research Reviews, 2023 - Elsevier
The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Adipokines at the crossroads of obesity and mesenchymal stem cell therapy

DV Pham, TK Nguyen, PH Park - Experimental & Molecular Medicine, 2023 - nature.com
Mesenchymal stem cell (MSC) therapy is an emerging treatment strategy to counteract
metabolic syndromes, including obesity and its comorbid disorders. However, its …

Using adipose‐derived mesenchymal stem cells to fight the metabolic complications of obesity: Where do we stand?

A Mikłosz, BE Nikitiuk, A Chabowski - Obesity Reviews, 2022 - Wiley Online Library
Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence
is increasing worldwide. Stem cell‐based therapies have become a promising tool for …

Translating MSC therapy in the age of obesity

L Boland, LM Bitterlich, AE Hogan, JA Ankrum… - Frontiers in …, 2022 - frontiersin.org
Mesenchymal stromal cell (MSC) therapy has seen increased attention as a possible option
to treat a number of inflammatory conditions including COVID-19 acute respiratory distress …

[HTML][HTML] Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders

MA Shibu, YJ Lin, CY Chiang, CY Lu… - Biomedicine & …, 2022 - Elsevier
Common characteristics of aging include reduced somatic stem cell number, susceptibility to
cardiac injuries, metabolic imbalances and increased risk for oncogenesis. In this study …

Muscle and adipose tissue communicate with extracellular vesicles

S Rome - International Journal of Molecular Sciences, 2022 - mdpi.com
In numerous body locations, muscle and adipose tissue are in close contact. Both tissues
are endocrine organs that release cytokines, playing a crutial role in the control of tissue …

Management of obesity and obesity-related disorders: from stem cells and epigenetics to its treatment

S Cruciani, AP Delitala, ML Cossu, C Ventura… - International Journal of …, 2023 - mdpi.com
Obesity is a complex worldwide disease, characterized by an abnormal or excessive fat
accumulation. The onset of this pathology is generally linked to a complex network of …

Influence of type 2 diabetes and obesity on adipose mesenchymal stem/stromal cell immunoregulation

M Mahmoud, M Abdel-Rasheed - Cell and Tissue Research, 2023 - Springer
Abstract Type 2 diabetes (T2D), associated with obesity, represents a state of metabolic
inflammation and oxidative stress leading to insulin resistance and progressive insulin …

Gene therapy based on mesenchymal stem cells derived from adipose tissue for the treatment of obesity and its metabolic complications

M Lopez-Yus, MP García-Sobreviela… - International Journal of …, 2023 - mdpi.com
Obesity is a highly prevalent condition often associated with dysfunctional adipose tissue.
Stem cell-based therapies have become a promising tool for therapeutic intervention in the …

Efficacy of adipose‐derived mesenchymal stem cell therapy in the treatment of chronic micro‐and macrovascular complications of diabetes

A Mikłosz, A Chabowski - Diabetes, Obesity and Metabolism, 2024 - Wiley Online Library
Diabetes mellitus is a highly prevalent disease characterized by hyperglycaemia that
damages the vascular system, leading to micro‐(retinopathy, neuropathy, nephropathy) and …