Following introduction of the monoamine oxidase type B inhibitor selegiline for the treatment
of Parkinson's disease (PD), discovery of the action mechanism of Alzheimer's disease …

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …

Neuregulin 1 (NRG1) is a trophic factor thought to play a role in neural development. Recent
studies suggest that it may regulate neurotransmission, mechanisms of which remain …

Mouse models that recapitulate the full phenotypic spectrum of a psychiatric disorder, such
as schizophrenia, are impossible. However, a more piecemeal recreation of phenotypic …

Alterations in glutamate, the primary excitatory neurotransmitter in the brain, are implicated
in several psychiatric diseases. Many of these psychiatric diseases display epidemiological …

Neuregulin-1 (NRG1) has been identified as a candidate susceptibility gene for
schizophrenia. In the present study the functional role of the NRG1 gene, as it relates to …

Rationale Cannabis use may precipitate schizophrenia especially if the individual has a
genetic vulnerability to this mental disorder. Human and animal research indicates that …

Neuregulin-1 (Nrg1)/erbB signaling regulates neuronal development, migration,
myelination, and synaptic maintenance. The Nrg1 gene is a schizophrenia susceptibility …