Small synthetic molecules called growth hormone secretagogues (GHSs) stimulate the
release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G protein …

Ghrelin is brain-gut peptide with growth hormone-releasing and appetite-inducing activities.
It is mainly secreted from the stomach mucosa but it is also expressed widely in different …

Background: The exclusion of the proximal small intestine is thought to play a major role in
the rapid improvement in the metabolic control of diabetes after gastric bypass. Objective: In …

Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the
pulsatile pattern of GH-release in the elderly, and increase lean but not fat mass in obese …

Objective: To evaluate interactions among leptin, adiponectin, resistin, ghrelin, and
proinflammatory cytokines [tumor necrosis factor receptors (TNFRs), interleukin‐6 (IL‐6)] in …

Ghrelin, an acylated upper gastrointestinal peptide, is the only known orexigenic hormone.
Considerable evidence implicates ghrelin in mealtime hunger and meal initiation …

Background: Different changes of plasma ghrelin levels have been reported following
gastric banding, Roux-en-Y gastric bypass, and biliopancreatic diversion. Methods: This …

Obesity is now a global pandemic that continues to accelerate despite the often Herculean
efforts by afflicted individuals to lose weight. These efforts are thwarted by a physiological …

Various bariatric surgical procedures are effective at improving health in patients with
obesity associated co-morbidities, but the aim of this review is to specifically describe the …

Despite dramatic fluctuations in calorie intake, animals maintain a very stable body weight.
The reason is that energy intake and expenditure are precisely matched. Long-term …