Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …

DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …

BRCA2-mutant cells are defective in homologous recombination, making them vulnerable to
the inactivation of other pathways for the repair of DNA double-strand breaks (DSBs). This …

Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

Homologous recombination (HR) comprises a series of interrelated pathways that function in
the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In …

The budding yeast Saccharomyces cerevisiae has been the principal organism used in
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …

The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome
stability and cell survival. Homologous recombination provides an efficient and faithful …