Advances in genome editing through control of DNA repair pathways

CD Yeh, CD Richardson, JE Corn - Nature cell biology, 2019 - nature.com
Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …

Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes

L Ranjha, SM Howard, P Cejka - Chromosoma, 2018 - Springer
DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …

POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis

M Llorens-Agost, M Ensminger, HP Le, A Gawai… - Nature cell …, 2021 - nature.com
BRCA2-mutant cells are defective in homologous recombination, making them vulnerable to
the inactivation of other pathways for the repair of DNA double-strand breaks (DSBs). This …

An overview of the molecular mechanisms of recombinational DNA repair

SC Kowalczykowski - Cold Spring Harbor Perspectives …, 2015 - cshperspectives.cshlp.org
Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

LS Symington, R Rothstein, M Lisby - Genetics, 2014 - academic.oup.com
Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

Mechanism of eukaryotic homologous recombination

J San Filippo, P Sung, H Klein - Annu. Rev. Biochem., 2008 - annualreviews.org
Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

Homologous recombination in DNA repair and DNA damage tolerance

X Li, WD Heyer - Cell research, 2008 - nature.com
Homologous recombination (HR) comprises a series of interrelated pathways that function in
the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In …

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

F Pâques, JE Haber - Microbiology and molecular biology reviews, 1999 - Am Soc Microbiol
The budding yeast Saccharomyces cerevisiae has been the principal organism used in
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …

Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

LS Symington - Microbiology and molecular biology reviews, 2002 - Am Soc Microbiol
The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

Molecular views of recombination proteins and their control

SC West - Nature reviews Molecular cell biology, 2003 - nature.com
The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome
stability and cell survival. Homologous recombination provides an efficient and faithful …