The vital roles of microtubule in mitosis and cell division make it an attractive target for
antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that …

Since microtubules have an important role in mitosis and other vital cellular functions,
tubulin-targeting chemotherapy has been received growing attention in anticancer drug …

This work describes about the synthesis and evaluation of substituted benzofuran
piperazines as potential anticancer agents. The synthesized candidates have been …

The development of chalcones as antimitotic agents has led to the design of other
analogues able to interact with tubulin and inhibit its assembly into microtubules. This …

Tubulin protein is one of several members of a small family of globular proteins. It offers a
potential target for anticancer drug design and development. Combretastatin A-4 (CA-4) is a …

This study deals with synthesis of a new set of benzofuran and 5 H-furo [3, 2-g] chromone
linked various heterocyclic functionalities using concise synthetic approaches aiming to gain …

Novel structural hybrids of benzofuran–oxadiazole and benzofuran–triazole have been
synthesized and evaluated for their potential against Staphylococcus aureus, Bacillus …

A novel series of shikonin-benzo [b] furan derivatives were designed and synthesized as
tubulin polymerization inhibitors, and their biological activities were evaluated. Most …

Microtubules are cytoskeletal components that play important roles in a number of cellular
processes. Colchicine binding site inhibitors (CSIs) is one major class of tubulin …

Tubulin protein is a highly imperative and feasible goal for anticancer drug discovery.
Hundreds of naturally occurring, semi synthetic and synthetic antitubulin agents have been …