Insights into RNA structure and function from genome-wide studies
SA Mortimer, MA Kidwell, JA Doudna - Nature Reviews Genetics, 2014 - nature.com
A comprehensive understanding of RNA structure will provide fundamental insights into the
cellular function of both coding and non-coding RNAs. Although many RNA structures have …
cellular function of both coding and non-coding RNAs. Although many RNA structures have …
Advances in RNA structure analysis by chemical probing
KM Weeks - Current opinion in structural biology, 2010 - Elsevier
RNA is arguably the most versatile biological macromolecule because of its ability both to
encode and to manipulate genetic information. The diverse roles of RNA depend on its …
encode and to manipulate genetic information. The diverse roles of RNA depend on its …
RNA design rules from a massive open laboratory
Self-assembling RNA molecules present compelling substrates for the rational interrogation
and control of living systems. However, imperfect in silico models—even at the secondary …
and control of living systems. However, imperfect in silico models—even at the secondary …
Inferring protein 3D structure from deep mutation scans
We describe an experimental method of three-dimensional (3D) structure determination that
exploits the increasing ease of high-throughput mutational scans. Inspired by the success of …
exploits the increasing ease of high-throughput mutational scans. Inspired by the success of …
Advances in RNA 3D structure modeling using experimental data
RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …
biological functions in a variety of molecular processes, including transcription, splicing …
Physics-based de novo prediction of RNA 3D structures
Current experiments on structural determination cannot keep up the pace with the steadily
emerging RNA sequences and new functions. This underscores the request for an accurate …
emerging RNA sequences and new functions. This underscores the request for an accurate …
Theory and modeling of RNA structure and interactions with metal ions and small molecules
In addition to continuous rapid progress in RNA structure determination, probing, and
biophysical studies, the past decade has seen remarkable advances in the development of …
biophysical studies, the past decade has seen remarkable advances in the development of …
SeqFold: genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data
We present an integrative approach, SeqFold, that combines high-throughput RNA structure
profiling data with computational prediction for genome-scale reconstruction of RNA …
profiling data with computational prediction for genome-scale reconstruction of RNA …
A two-dimensional mutate-and-map strategy for non-coding RNA structure
W Kladwang, CC VanLang, P Cordero, R Das - Nature chemistry, 2011 - nature.com
Non-coding RNAs fold into precise base-pairing patterns to carry out critical roles in genetic
regulation and protein synthesis, but determining RNA structure remains difficult. Here, we …
regulation and protein synthesis, but determining RNA structure remains difficult. Here, we …
Modeling complex RNA tertiary folds with Rosetta
Reliable modeling of RNA tertiary structures is key to both understanding these structures'
roles in complex biological machines and to eventually facilitating their design for molecular …
roles in complex biological machines and to eventually facilitating their design for molecular …