Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex
interplay of several pathways, including inflammation, immune activation, hypoxia, and …

Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers
immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop …

Patients who survive sepsis can develop long-term immune dysfunction, with expansion of
the regulatory T (Treg) cell population. However, how Treg cells proliferate in these patients …

Introduction Severe sepsis continues to be a significant burden on society. Methods Using
the International Classification of Diseases, Ninth Revision, Clinical Modification codes, we …

Chronic inflammation and fibrosis can result from inappropriately activated immune
responses that are mediated by macrophages. Macrophages can acquire memory-like …

Sepsis is life-threating organ dysfunction due to infection. Incidence of sepsis is increasing
and the short-term mortality is improving, generating more sepsis survivors. These sepsis …

Background The sequelae of sepsis were once thought to be independent of sepsis itself
and assumed to be either comorbid to sick patients or complications of critical illness …

Purpose Sepsis survivors have a higher risk of rehospitalisation and of long-term mortality.
We assessed the rate, diagnosis, and independent predictors for rehospitalisation in adult …