Abstract The Human Proteome Organization (HUPO) launched the Human Proteome Project
(HPP) in 2010, creating an international framework for global collaboration, data sharing …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era.
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …

Deep learning algorithms are powerful tools for analyzing, restoring and transforming
bioimaging data. One promise of deep learning is parameter-free one-click image analysis …

For a complete understanding of a system's processes and each protein's role in health and
disease, it is essential to study protein expression with a spatial resolution, as the exact …

The cell is a multi-scale structure with modular organization across at least four orders of
magnitude. Two central approaches for mapping this structure—protein fluorescent imaging …

Explaining the diversity and complexity of protein localization is essential to fully understand
cellular architecture. Here we present cytoself, a deep-learning approach for fully self …

The last decade has witnessed a technological arms race to encode the molecular states of
cells into DNA libraries, turning DNA sequencers into scalable single-cell microscopes …

A cell's phenotype is the culmination of several cellular processes through a complex
network of molecular interactions that ultimately result in a unique morphological signature …

The nucleolus is essential for ribosome biogenesis and is involved in many other cellular
functions. We performed a systematic spatiotemporal dissection of the human nucleolar …