According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Better biomarkers are urgently needed to improve diagnosis, guide molecularly targeted
therapy and monitor activity and therapeutic response across a wide spectrum of disease …

Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …

Separation of polar compounds on polar stationary phases with partly aqueous eluents is by
no means a new separation mode in LC. The first HPLC applications were published more …

Two-dimensional liquid chromatography is often used to reduce the proteomic sample
complexity prior to tandem mass spectrometry analysis. The 2D-LC performance depends …

Human blood plasma can be obtained relatively noninvasively and contains proteins from
most, if not all, tissues of the body. Therefore, an extensive, quantitative catalog of plasma …

The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …

Biomarker discovery produces lists of candidate markers whose presence and level must be
subsequently verified in serum or plasma. Verification represents a paradigm shift from …

HUPO initiated the Plasma Proteome Project (PPP) in 2002. Its pilot phase has (1) evaluated
advantages and limitations of many depletion, fractionation, and MS technology …

Introduction: Intravenously injected nanoparticles, like any other foreign pathogen that
enters the body, encounter multiple lines of defense intended to neutralize and eliminate the …