Abstract Serotonin (5-HT), a well-known neurotransmitter in the brain, also plays an
important role in peripheral tissues, including the immune system. There is a growing body …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …

Melatonin, or N‐acetyl‐5‐methoxytryptamine, is a compound derived from tryptophan that is
found in all organisms from unicells to vertebrates. This indoleamine may act as a protective …

Green tea polyphenols (GTP) are thought to help prevent oxidative stress-related diseases,
such as cancer, cardiovascular disease, neurodegenerative disease, and aging. We here …

Amyloid beta-protein (Aβ) is the major component of senile plaques and cerebrovascular
amyloid deposits in individuals with Alzheimer's disease. Aβ is known to increase free …

Tryptophan is an essential amino acid with a huge functional versatility, in addition to its
participation in protein synthesis. Because of the complexity of its metabolism, and the …

Melatonin is a versatile molecule, synthesized not only by the pineal gland, but also in small
amounts by many other organs like retina, gastrointestinal tract, thymus, bone marrow …

Stroke causes death and disability globally but no neuroprotectant is approved for post-
stroke neuronal injury. Neuroprotective compounds can be identified using oxygen glucose …

Parkinson's disease (PD) involves an initial loss of striatal dopaminergic terminals evolving
into a degeneration of dopaminergic neurons in the substantia nigra (SN), which can be …