Update on Chlamydia trachomatis vaccinology

LM de la Maza, G Zhong… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Attempts to produce a vaccine to protect against Chlamydia trachomatis-induced trachoma
were initiated more than 100 years ago and continued for several decades. Using whole …

Chlamydial plasmid-dependent pathogenicity

G Zhong - Trends in microbiology, 2017 - cell.com
Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice

Y Liu, Y Huang, Z Yang, Y Sun, S Gong… - Infection and …, 2014 - Am Soc Microbiol
Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been
used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic …

[HTML][HTML] The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg

JN Bugalhão, LJ Mota - Microbial Cell, 2019 - ncbi.nlm.nih.gov
Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly
causing ocular and urogenital infections that affect millions of people worldwide and which …

Defining seropositivity thresholds for use in trachoma elimination studies

SJ Migchelsen, DL Martin… - PLoS Neglected …, 2017 - journals.plos.org
Background Efforts are underway to eliminate trachoma as a public health problem by 2020.
Programmatic guidelines are based on clinical signs that correlate poorly with Chlamydia …

[HTML][HTML] Plasmid-mediated virulence in Chlamydia

BJ Turman, T Darville, CM O'Connell - Frontiers in Cellular and …, 2023 - ncbi.nlm.nih.gov
Chlamydia trachomatis infection of ocular conjunctiva can lead to blindness, while infection
of the female genital tract can lead to chronic pelvic pain, ectopic pregnancy, and/or …

Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37

S Hou, X Dong, Z Yang, Z Li, Q Liu… - Infection and …, 2015 - Am Soc Microbiol
Chlamydia trachomatis infection in the lower genital tract can ascend to and cause
pathologies in the upper genital tract, potentially leading to severe complications, such as …

Chlamydia overcomes multiple gastrointestinal barriers to achieve long-lasting colonization

G Zhong - Trends in microbiology, 2021 - cell.com
Chlamydia trachomatis (CT) is frequently detected in the human gastrointestinal (GI) tract
despite its leading role in sexually transmitted bacterial infections in the genital tract …

National Institute of Allergy and Infectious Diseases workshop report:“Chlamydia vaccines: The way forward”

G Zhong, RC Brunham, LM de la Maza, T Darville… - Vaccine, 2019 - Elsevier
Chlamydia trachomatis (Ct), an intracellular pathogen, is the most common bacterial
sexually transmitted infection. In addition to acute cervicitis and urethritis, Ct can lead to …

Chlamydia spreading from the genital tract to the gastrointestinal tract–a two-hit hypothesis

G Zhong - Trends in microbiology, 2018 - cell.com
Chlamydia trachomatis, a leading bacterial cause of sexually transmitted infection-induced
infertility, is frequently detected in the gastrointestinal tract. Chlamydia muridarum, a model …