According to current estimates, infertility affects one in four couples trying to conceive.
Primary or secondary infertility can be due either to both partners or only to the man or the …

The accidental amplification of nuclear mitochondrial pseudogenes (NUMTs) can pose a
serious problem for mitochondrial disease studies. This report shows that the mutation …

Rewiring of energy metabolism and adaptation of mitochondria are considered to impact on
prostate cancer development and progression. Here, we report on mitochondrial respiration …

Heterogeneous clinical expression of mitochondrial DNA (mtDNA) disorders depends on
both qualitative and quantitative changes in mtDNA. We developed a sensitive and effective …

Although mitochondrial disorders are increasingly being recognized, confirming a specific
diagnosis remains a great challenge due to the genetic and clinical heterogeneity of the …

Mitochondrial disorders are increasingly being diagnosed, especially among patients with
multiple, seemingly unrelated, neuromuscular and multi-sytem disorders. The genetics are …

The anticodon stem-loop of tRNAs requires extensive posttranscriptional modifications in
order to maintain structure and stabilize the codon-anticodon interaction. These …

Background Although advances in sequencing technologies have popularized the use of
microRNA (miRNA) sequencing (miRNA-seq) for the quantification of miRNA expression …

The human mitochondrial genome encodes 13 proteins. All are subunits of the respiratory
chain complexes involved in energy metabolism. These proteins are translated by a set of …

Mitochondrial DNA (mtDNA) mutations have been described in almost all types of cancer.
However, their exact role and timing of occurrence during tumor development and …