AS (alternative splicing) is a fundamental process by which a gene can generate multiple
distinct mRNA transcripts to increase protein diversity. Defects in AS influence the …

Polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is
expressed in almost all cell types in humans, unlike the other proteins of the PTBP family …

Long noncoding RNAs (lncRNAs) are a class of transcripts longer than 200 nucleotides with
no open reading frame. They play a key role in the regulation of cellular processes such as …

In eukaryotes, alternative splicing refers to a process via which a single precursor RNA (pre-
RNA) is transcribed into different mature RNAs. Thus, alternative splicing enables the …

Although mammals possess roughly the same number of protein-coding genes as worms, it
is evident that the non-coding transcriptome content has become far broader and more …

Alternative splicing (AS) serves as an additional regulatory process for gene expression
after transcription, and it generates distinct mRNA species, and even noncoding RNAs …

Bone metastases are frequent complications in patients with advanced cancer, which can be
fatal or may rapidly impede the quality of life of patients. Current treatments for patients with …

Chemo and radiation therapies are the most commonly used therapies for cancer, but they
can induce DNA damage, resulting in the apoptosis of host cells. DNA double-stranded …

Abstract Background Long non-coding RNAs (lncRNAs) regulate diverse biological
processes via interactions with proteins. Since the experimental methods to identify these …

Long noncoding RNAs (lncRNAs) constitute a significant fraction of mammalian
transcriptomes and they have emerged as intricate regulators of many biological processes …