New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland

M Coca-Prados, J Escribano - Progress in retinal and eye research, 2007 - Elsevier
The discovery in the human ocular ciliary body of glaucoma-associated genes (ie, MYOC,
CYP1B1), neuroendocrine processing enzymes, neuroendocrine peptides, steroid …

Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma

AR Stothert, SN Fontaine, JJ Sabbagh… - Experimental eye …, 2016 - Elsevier
A major drainage network involved in aqueous humor dynamics is the conventional outflow
pathway, which is gated by the trabecular meshwork (TM). The TM acts as a molecular …

The glycoprotein hGC-1 binds to cadherin and lectins

W Liu, L Chen, J Zhu, GP Rodgers - Experimental cell research, 2006 - Elsevier
Human granulocyte colony stimulating factor stimulated clone-1 (hGC-1, also known as
GW112, OLM4, and hOlfD) is an olfactomedin-related glycoprotein of unknown function. We …

Cleavage and oligomerization of gliomedin, a transmembrane collagen required for node of ranvier formation

B Maertens, D Hopkins, CW Franzke, DR Keene… - Journal of Biological …, 2007 - ASBMB
Gliomedin, which has been implicated as a major player in genesis of the nodes of Ranvier,
contains two collagenous domains and an olfactomedin-like domain and belongs to the …

Functional analysis of the glaucoma-causing TIGR/myocilin protein: integrity of amino-terminal coiled-coil regions and olfactomedin homology domain is essential for …

S Gobeil, L Letartre, V Raymond - Experimental eye research, 2006 - Elsevier
TIGR/MYOC mutations account for 2–4% of the primary open-angle glaucoma (POAG)
patients. More than 90% of the known mutations are located within its carboxy-terminus …

Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227

JD Aroca-Aguilar, F Sánchez-Sánchez, S Ghosh… - Journal of Biological …, 2005 - ASBMB
Myocilin is a secreted glycoprotein of unknown function that is ubiquitously expressed in
many human organs, including the eye. Mutations in this protein produce glaucoma, a …

[HTML][HTML] Elucidation of subfamily segregation and intramolecular coevolution of the olfactomedin-like proteins by comprehensive phylogenetic analysis and gene …

LC Zeng, ZG Han, WJ Ma - FEBS letters, 2005 - Elsevier
The categorization of genes by structural distinctions relevant to biological characteristics is
very important for understanding of gene functions and predicting functional implications of …

The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder

JN Burns, KC Turnage, CA Walker, RL Lieberman - Biochemistry, 2011 - ACS Publications
Myocilin variants, localized to the olfactomedin (OLF) domain, are linked to early-onset,
inherited forms of open-angle glaucoma. Disease-causing myocilin variants accumulate …

Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones

JN Burns, SD Orwig, JL Harris, JD Watkins… - ACS chemical …, 2010 - ACS Publications
Mutations in myocilin cause an inherited form of open angle glaucoma, a prevalent
neurodegenerative disorder associated with increased intraocular pressure. Myocilin forms …

Identification of new sphingomyelinases D in pathogenic fungi and other pathogenic organisms

C Dias-Lopes, IAP Neshich, G Neshich, JM Ortega… - PLoS …, 2013 - journals.plos.org
Sphingomyelinases D (SMases D) or dermonecrotic toxins are well characterized in
Loxosceles spider venoms and have been described in some strains of pathogenic …