Amantadine in the treatment of Parkinson's disease and other movement disorders

O Rascol, M Fabbri, W Poewe - The Lancet Neurology, 2021 - thelancet.com
The efficacy of amantadine in the symptomatic treatment of patients with Parkinson's
disease, discovered serendipitously more than 50 years ago, has stood the test of time and …

Levodopa-induced dyskinesia in Parkinson's disease: pathogenesis and emerging treatment strategies

DK Kwon, M Kwatra, J Wang, HS Ko - Cells, 2022 - mdpi.com
The most commonly used treatment for Parkinson's disease (PD) is levodopa, prescribed in
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …

[HTML][HTML] Parkinson's disease and its management: part 1: disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis

G DeMaagd, A Philip - Pharmacy and therapeutics, 2015 - ncbi.nlm.nih.gov
Parkinson’s Disease and Its Management - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search …

Direct and indirect pathways of basal ganglia: a critical reappraisal

P Calabresi, B Picconi, A Tozzi, V Ghiglieri… - Nature …, 2014 - nature.com
The basal ganglia are subcortical nuclei controlling voluntary actions and have been
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

MF Bastide, WG Meissner, B Picconi, S Fasano… - Progress in …, 2015 - Elsevier
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

In silico molecular docking analysis of karanjin against alzheimer's and parkinson's diseases as a potential natural lead molecule for new drug design, development …

C Gnanaraj, M Sekar, S Fuloria, SS Swain, SH Gan… - Molecules, 2022 - mdpi.com
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
that have emerged as among the serious health problems of the 21st century. The …

Levodopa in Parkinson's disease: current status and future developments

N Tambasco, M Romoli… - Current …, 2018 - ingentaconnect.com
Background: Ever since the pioneering reports in the 60s, L-3, 4-Dioxyphenylalanine
(levodopa) has represented the gold standard for the treatment of Parkinson's Disease (PD) …

Clinical spectrum of levodopa‐induced complications

CC Aquino, SH Fox - Movement Disorders, 2015 - Wiley Online Library
The first years of Parkinson disease (PD) treatment are marked by good and sustained
responses to dopaminergic therapy. With disease progression and longer exposure to …

Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts

KA Jellinger - Movement disorders, 2012 - Wiley Online Library
Abstract Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is
no longer considered a complex motor disorder characterized by extrapyramidal symptoms …

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain

N Watamura, N Kakiya, R Fujioka, N Kamano… - Science …, 2024 - science.org
Deposition of amyloid-β (Aβ) in the brain can impair neuronal function and contribute to
cognitive decline in Alzheimer's disease (AD). Here, we found that dopamine and the …