In contrast to other fat-soluble vitamins, dietary vitamin K is rapidly lost to the body resulting
in comparatively low tissue stores. Deficiency is kept at bay by the ubiquity of vitamin K in the …

Vitamin K‐dependent proteins require carboxylation of certain glutamates for their biological
functions. The enzymes involved in the vitamin K‐dependent carboxylation include: gamma …

Vitamin K is a vital micronutrient implicated in a variety of human diseases. Warfarin, a
vitamin K antagonist, is the most commonly prescribed oral anticoagulant. Patients …

Vitamin K (VK) is an essential cofactor for the post-translational conversion of peptide-bound
glutamate to γ-carboxyglutamate. The resultant vitamin K–dependent proteins are known or …

Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-
dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant …

INTRODUCTION Vitamin K antagonists (VKAs), such as warfarin, are oral anticoagulants
commonly used to treat and prevent thromboembolic diseases, including stroke and heart …

Although warfarin is the most widely used anticoagulant worldwide, the mechanism by
which warfarin inhibits its target, human vitamin K epoxide reductase (hVKOR), remains …

Osteocalcin (OCN) is an osteoblast-derived hormone favoring glucose homeostasis, energy
expenditure, male fertility, brain development, and cognition. Before being secreted by …

As costs of next-generation sequencing decrease, identification of genetic variants has far
outpaced our ability to understand their functional consequences. This lack of understanding …

Vitamin K epoxide reductase (VKOR), an endoplasmic reticulum membrane protein, is the
key enzyme for vitamin K–dependent carboxylation, a posttranslational modification that is …