Adipokine dysregulation and adipose tissue inflammation in human obesity

X Unamuno, J Gómez‐Ambrosi… - European journal of …, 2018 - Wiley Online Library
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …

Relevance of leptin and other adipokines in obesity-associated cardiovascular risk

MF Landecho, C Tuero, V Valentí, I Bilbao… - Nutrients, 2019 - mdpi.com
Obesity, which is a worldwide epidemic, confers increased risk for multiple serious
conditions including type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular …

Macrophage functions in lean and obese adipose tissue

D Thomas, C Apovian - Metabolism, 2017 - Elsevier
Interactions between macrophages and adipocytes influence both metabolism and
inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic …

NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

X Unamuno, J Gómez-Ambrosi, B Ramírez… - Cellular & molecular …, 2021 - nature.com
Abstract The NLRP3-IL-1β pathway plays an important role in adipose tissue (AT)-induced
inflammation and the development of obesity-associated comorbidities. We aimed to …

Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker

GA Baselli, P Dongiovanni, R Rametta, M Meroni… - Gut, 2020 - gut.bmj.com
Objective Efforts to manage non-alcoholic fatty liver disease (NAFLD) are limited by the
incomplete understanding of the pathogenic mechanisms and the absence of accurate non …

Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH)

A Do, F Zahrawi, WZ Mehal - Nature Reviews Drug Discovery, 2024 - nature.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its severe subgroup
metabolic dysfunction-associated steatohepatitis (MASH) have become a global epidemic …

Molecular interactions and functions of IL-32

KR Aass, MH Kastnes, T Standal - Journal of Leucocyte Biology, 2021 - academic.oup.com
IL-32 is a multifaceted cytokine associated with several diseases and inflammatory
conditions. Its expression is induced in response to cellular stress such as hypoxia …

[HTML][HTML] Genetic predisposition similarities between NASH and ASH: identification of new therapeutic targets

C Bianco, E Casirati, F Malvestiti, L Valenti - JHEP Reports, 2021 - Elsevier
Fatty liver disease can be triggered by a combination of excess alcohol, dysmetabolism and
other environmental cues, which can lead to steatohepatitis and can evolve to acute/chronic …

Physiological changes and pathological pain associated with sedentary lifestyle-induced body systems fat accumulation and their modulation by physical exercise

E Verdú, J Homs, P Boadas-Vaello - International journal of …, 2021 - mdpi.com
A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …

Abdominal subcutaneous adipose tissue: a favorable adipose depot for diabetes?

P Chen, X Hou, G Hu, L Wei, L Jiao, H Wang… - Cardiovascular …, 2018 - Springer
Background Previous studies have documented that visceral adipose tissue is positively
associated with the risk of diabetes. However, the association of subcutaneous adipose …