Revisiting the neurovascular unit

S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

The role of inflammasomes in vascular cognitive impairment

L Poh, WL Sim, DG Jo, QN Dinh, GR Drummond… - Molecular …, 2022 - Springer
There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR‐93‐Mediated TLR4/MyD88/NF‐κB Signaling Pathway

L Wang, JW Yang, LT Lin, J Huang… - Oxidative Medicine …, 2020 - Wiley Online Library
Background. It is widely accepted that inflammation may contribute to cognitive impairment
in patients with vascular dementia (VD). Our prior clinical researches have reported that …

Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis

C Custodero, A Ciavarella, F Panza, D Gnocchi… - Geroscience, 2022 - Springer
Vascular contribution to cognitive impairment and dementia (VCID) is a clinical label
encompassing a wide range of cognitive disorders progressing from mild to major vascular …

Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment

V Rajeev, YL Chai, L Poh, S Selvaraji, DY Fann… - Acta neuropathologica …, 2023 - Springer
Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …

[HTML][HTML] Measuring gait speed to better identify prodromal dementia

G Grande, F Triolo, A Nuara, AK Welmer… - Experimental …, 2019 - Elsevier
Slow gait speed has been shown to predict incident dementia and cognitive decline in older
individuals. We aimed to summarize the evidence concerning the association of slow gait …

[HTML][HTML] Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion

B Han, W Jiang, H Liu, J Wang, K Zheng, P Cui… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Mitochondrial dysfunction and oxidative stress occur in vascular dementia (VaD),
but the specific molecular mechanism regulating these events remains unclear. Peroxisome …

Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants

Y Shi, F Lin, Y Li, Y Wang, X Chen, F Meng, Q Ye… - BMC medicine, 2023 - Springer
Background Increasing evidence suggests an association between pro-inflammatory diets
and cognitive function. However, only a few studies based on small sample sizes have …

Time-dependent dual effect of microglia in ischemic stroke

P Fan, S Wang, S Chu, N Chen - Neurochemistry international, 2023 - Elsevier
Stroke, the third leading cause of death and disability worldwide, is classified into ischemic
or hemorrhagic, in which approximately 85% of strokes are ischemic. Ischemic stroke occurs …