Tumor neoantigen is the truly foreign protein and entirely absent from normal human
organs/tissues. It could be specifically recognized by neoantigen-specific T cell receptors …

It is now well established that the immune system can recognize developing cancers and
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …

Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses
may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features …

A variety of species of bacteria are known to colonize human tumours,,,,,,,,,–, proliferate
within them and modulate immune function, which ultimately affects the survival of patients …

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However …

CD8+ T cell–dependent killing of cancer cells requires efficient presentation of tumor
antigens by human leukocyte antigen class I (HLA-I) molecules. However, the extent to …

Defects in pathways governing genomic fidelity have been linked to improved response to
immune checkpoint blockade therapy (ICB). Pathogenic POLE/POLD1 mutations can cause …

Although clonal neo-antigen burden is associated with improved response to immune
therapy, the functional basis for this remains unclear. Here we study this question in a novel …

Importance Therapies to inhibit programmed cell death 1 and its ligand (anti–PD-1/PD-L1)
provide significant survival benefits in many cancers, but the efficacy of these treatments …

Compared with conventional chemotherapy and targeted therapy, immunotherapy has
changed the treatment prospects of various solid tumors and has recently become the main …