The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Fluid resuscitation after massive hemorrhage in major surgery and trauma may result in
extensive hemodilution and coagulopathy, which is of a multifactorial nature. Although …

Introduction The appropriate strategy for trauma-induced coagulopathy management is
under debate. We report the treatment of major trauma using mainly coagulation factor …

Introduction Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen
concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the …

Trauma promotes trauma‐induced coagulopathy, which requires urgent treatment with fixed‐
ratio transfusions of red blood cells, fresh frozen plasma and platelet concentrates, or goal …

Background Post-partum haemorrhage (PPH) causes rapidly developing deficiencies in
clotting factors and contributes to substantial maternal morbidity and mortality. Rotational …

Background Hypofibrinogenaemia is associated with increased morbidity and mortality, but
the optimal treatment level, the use of preemptive treatment and the preferred source of …

Globally, postpartum hemorrhage (PPH) is the leading cause of maternal morbidity and
mortality. In the current treatment of severe PPH, first-line therapy includes transfusion of …

Background: Thromboelastometry is a whole blood assay performed to evaluate the
viscoelastic properties during blood clot formation and lysis. Rotation thromboelastography …

Introduction Purified prothrombin complex concentrate (PCC) is increasingly used as
hemostatic therapy for trauma-induced coagulopathy (TIC). However, the impact of PCC …