Insulin-like growth factor 1 receptor (IGF1R) is a prevalent signaling pathway in human
cancer that supports cell growth/survival and thus contributes to aggressive biological …

Background Tenalisib (RP6530) is a novel, highly specific, dual phosphoinositide-3 kinases
(PI3K) δ/γ inhibitor with nano-molar potency. Material and Methods This was a phase I, open …

Peripheral T-cell non-Hodgkin lymphoma (PTCL) are heterogeneous, rare, and aggressive
diseases mostly incurable with current cell cycle therapies. Aurora kinases (AKs) are key …

PI3Kδ plays a critical role in adaptive immune cell activation and function. Suppression of
PI3Kδ has been shown to counter excessive triggering of immune responses which has led …

Clotrimazole (CTZ) has been proposed as an antitumoral agent because of its properties
that inhibit glycolytic enzymes and detach them from the cytoskeleton. However, the broad …

Abstract The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is emerging as a
promising therapeutic target for multiple myeloma (MM). In the present study, we performed …

Abstract Aberrant Class I PI3K signaling is a key factor contributing to many immunological
disorders and cancers. We have identified 4-amino pyrrolotriazine as a novel chemotype …

Multiple myeloma (MM) remains an incurable plasma cell malignancy and drug resistance
persists as the major cause of treatment failure leading to fatal outcomes. The phosphatidyl …

The phosphoinositide 3-kinase (PI3K) family of signalling enzymes play a key role in the
transduction of signals from activated cell surface receptors controlling cell growth and …

CITY OF HOPE 1500 E. DUARTE ROAD DUARTE, CA 91010 DEPARTMENT OF
HEMATOLOGY AND HEMATOPOIETIC CELL TRANSPLANTATION TITLE: A Phase Page 1 IRB …