5-Fluorouracil (5-FU) being a mainstream anticancer drug is under keen and detailed
investigation for prodrugs formulations in order to minimize the associated side effects …

This study reports the formation of 5-FU co-crystals with four different pharmacologically safe
co-formers; Urea, Thiourea, Acetanilide and Aspirin using methanol as a solvent. Two …

Pharmaceutical cocrystallization is proposed as a new method to enhance membrane
permeability of a BCS class III model drug, 5-fluorouracil (5FU). Three cocrystals of 5FU …

In the present investigation, 5-Fluorouracil co-crystals with four cyclic dimers of amino acids
(Glycine, Tryptophane, Leucine and Alanine conformers are prepared via co-crystallization …

Abstract Co-crystals of 5-fluorouracil (5-Fu) and the coformers urea, thiourea and
pyrazinamide (PZA) were attempted for the first time through the supercritical antisolvent …

In order to give full play to the superiority of cocrystallization techniques to overcome
biopharmaceutical limitations in vitro and ameliorate pharmacokinetic properties in vivo …

To fully play the advantages of cocrystallization and nano-preparation techniques in
regulating in vitro/vivo biopharmaceutical properties of anticancer drug 5-fluorouracil (FU) …

In order to highlight the advantages of L-phenylalanine (Phe) in the optimization of the in
vitro/vivo properties of the anticancer drug 5-fluorouracil (Fu) along with the enhancement in …

5-Fluorocytosine (5-FC) was investigated for the controlled synthesis of cocrystals by
applying the p K a rule. Five cocrystals were designed and developed with adipic, succinic …

5-Fluorouracil (5FU) is a classical anti-metabolic drug with broad-spectrum antitumor effects.
However, the oral absorption of 5FU is incomplete with a short biological half-life and an …