Insertions and deletions constitute the second most important source of natural genomic
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …

Co‐evolution has an important function in the evolution of species and it is clearly
manifested in certain scenarios such as host–parasite and predator–prey interactions …

Key amino acid positions that are important for maintaining the 3D structure of a protein
and/or its function (s), eg catalytic activity, binding to ligand, DNA or other proteins, are often …

Patterns observed by examining the evolutionary relationships among proteins of common
origin can reveal the structural and functional importance of specific residue positions. In …

The degree to which an amino acid site is free to vary is strongly dependent on its structural
and functional importance. An amino acid that plays an essential role is unlikely to change …

The resolution of four controversial topics in phylogenetic experimental design hinges upon
the informativeness of characters about the historical relationships among taxa. These …

The tailoring of existing genetic systems to new uses is called genetic co-option.
Mechanisms of genetic co-option have been difficult to study because of difficulties in …

DIVERGE is a software system for phylogeny-based analyses of protein family evolution and
functional divergence. It provides a suite of statistical tools for selection and prioritization of …

The coding sequences of developmental genes are expected to be deeply conserved, with
cis-regulatory change driving the modulation of gene function. In contrast, proteins with roles …

Perspectives on the classification of eukaryotic diversity have changed rapidly in recent
years, as the four eukaryotic groups within the five-kingdom classification—plants, animals …