Advances in biomedical Raman microscopy

KA Antonio, ZD Schultz - Analytical chemistry, 2014 - ACS Publications
The vibrational modes of molecules provide an intrinsic contrast mechanism for identifying
components in cells, tissues, and organisms. When excited by a laser, Raman scattered …

Histological coherent Raman imaging: a prognostic review

MT Cicerone, CH Camp - Analyst, 2018 - pubs.rsc.org
Histopathology plays a central role in diagnosis of many diseases including solid cancers.
Efforts are underway to transform this subjective art to an objective and quantitative science …

Hyperspectral and differential CARS microscopy for quantitative chemical imaging in human adipocytes

C Di Napoli, I Pope, F Masia, P Watson… - Biomedical optics …, 2014 - opg.optica.org
In this work, we demonstrate the applicability of coherent anti-Stokes Raman scattering
(CARS) micro-spectroscopy for quantitative chemical imaging of saturated and unsaturated …

Quantitative 3D molecular cutaneous absorption in human skin using label free nonlinear microscopy

X Chen, S Grégoire, F Formanek, JB Galey… - Journal of Controlled …, 2015 - Elsevier
Understanding the penetration mechanisms of drugs into human skin is a key issue in
pharmaceutical and cosmetics research. To date, the techniques available for percutaneous …

Amplitude and polarization modulated hyperspectral stimulated Raman scattering microscopy

M Andreana, MA Houle, DJ Moffatt, A Ridsdale… - Optics express, 2015 - opg.optica.org
We present a simple hyperspectral Stimulated Raman Scattering (SRS) microscopy method
based on spectral focusing of chirped femtosecond pulses, combined with amplitude (AM) …

Rapid 3D chemical‐specific imaging of minerals using stimulated Raman scattering microscopy

MA Houle, RC Burruss, A Ridsdale… - Journal of Raman …, 2017 - Wiley Online Library
Raman microscopy, which offers chemical‐specific imaging, has important applications in
geological sciences. Conventional Raman imaging, however, is challenged by long …

Hyperspectral volumetric coherent anti‐Stokes Raman scattering microscopy: quantitative volume determination and NaCl as non‐resonant standard

A Karuna, F Masia, P Borri… - Journal of Raman …, 2016 - Wiley Online Library
In this work, we demonstrate quantitative volume determination of chemical components in
three dimensions using hyperspectral coherent anti‐Stokes Raman scattering microscopy …

Direct visualization of the arterial wall water permeability barrier using CARS microscopy

BM Lucotte, C Powell, JR Knutson… - Proceedings of the …, 2017 - National Acad Sciences
The artery wall is equipped with a water permeation barrier that allows blood to flow at high
pressure without significant water leak. The precise location of this barrier is unknown …

Effects of refractive index mismatch on SRS and CARS microscopy

J van der Kolk, AC Lesina, L Ramunno - Optics Express, 2016 - opg.optica.org
An inhomogeneous linear refractive index profile, such as that occurring in biological
tissues, is shown to significantly alter stimulated Raman scattering (SRS) and coherent anti …

Impact of refractive index mismatches on coherent anti-Stokes Raman scattering and multiphoton autofluorescence tomography of human skin in vivo

M Weinigel, HG Breunig, ME Darvin… - Physics in Medicine …, 2015 - iopscience.iop.org
Optical non-linear multimodal tomography is a powerful diagnostic imaging tool to analyse
human skin based on its autofluorescence and second-harmonic generation signals …