Sulfhydryl groups as targets of mercury toxicity

OP Ajsuvakova, AA Tinkov, M Aschner… - Coordination chemistry …, 2020 - Elsevier
The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol;-
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …

[HTML][HTML] Methylmercury's chemistry: From the environment to the mammalian brain

PA Nogara, CS Oliveira, GL Schmitz, PC Piquini… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Methylmercury is a neurotoxicant that is found in fish and rice. MeHg's toxicity is mediated by
blockage of-SH and-SeH groups of proteins. However, the identification of MeHg's targets is …

Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (Mpro) and Papain-like Protease (PLpro)

FB Omage, A Madabeni, AR Tucci… - Journal of Chemical …, 2023 - ACS Publications
The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …

Mercury and prenatal growth: a systematic review

K Dack, M Fell, CM Taylor, A Havdahl… - International journal of …, 2021 - mdpi.com
The intrauterine environment is critical for healthy prenatal growth and affects neonatal
survival and later health. Mercury is a toxic metal which can freely cross the placenta and …

Exposure to thimerosal induces behavioral abnormality in the early life stages of zebrafish via altering amino acid homeostasis

X Qiu, Y Zhang, J Gao, Y Cui, K Dong, K Chen… - Journal of Hazardous …, 2024 - Elsevier
Thimerosal (THI) has become a significant source of organic mercury pollutants in aquatic
ecosystems, but there is limited information regarding its adverse effects on fish. In this …

Prenatal mercury exposure and neurodevelopment up to the age of 5 years: A systematic review

K Dack, M Fell, CM Taylor, A Havdahl… - International Journal of …, 2022 - mdpi.com
Neurodevelopmental delays can interfere with children's engagement with the world and
further development, and may have negative consequences into adulthood. Mercury is …

Toxicological Effects of Thimerosal and Aluminum in the Liver, Kidney, and Brain of Zebrafish (Danio rerio)

MEA Galiciolli, JF Silva, MM Prodocimo, HA Laureano… - Metabolites, 2023 - mdpi.com
Vaccination programs in the first years of a child's life are effective and extremely important
strategies for the successful eradication of diseases. However, as no intervention is without …

Toxic metals that interact with thiol groups and alteration in insect behavior

CS Oliveira, PA Nogara, LS Lima, MEA Galiciolli… - Current Opinion in Insect …, 2022 - Elsevier
Highlights•Toxic metals (TM) are ubiquitous, and insects are susceptible to
contamination.•TM mechanism of toxicity in insects is related to interaction with–SH …

Organic selenocompounds: are they the panacea for human illnesses?

PA Nogara, ME Pereira, CS Oliveira, L Orian… - New Journal of …, 2023 - pubs.rsc.org
The selenium element is essential to some life forms and its biological-chemistry function is
mainly performed by the selenol/selenolate moiety (–SeH/–Se–) in a few selenoproteins …

Neurotoxic effects of combined exposures to aluminum and mercury in early life (infancy)

JG Dórea - Environmental Research, 2020 - Elsevier
Aluminum and mercury are environmentally ubiquitous. Individually they are both neurotoxic
elements with shared neuro-pathogenic pathways: oxidative stress, altered …