Introduction Convection-enhanced delivery (CED) is a method of targeted, local drug
delivery to the central nervous system (CNS) that bypasses the blood-brain barrier (BBB) …

As the mainstay in the treatment of various cancers for several decades, chemotherapy is
successful but still faces challenges including non-selectivity and high toxicity. Improving the …

Previous uncontrolled clinical trials have shown the in vivo retrovirus (RV)-mediated
transduction of glioblastoma cells with the herpes simplex virus thymidine kinase (HSV-tk) …

Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor
prognosis. Attempts to develop targeted therapies have been hindered because the blood …

Diseases of the nervous system have devastating effects and are widely distributed among
the population, being especially prevalent in the elderly. These diseases are often caused …

Primary brain tumors have a significant infiltrative capacity as their reappearance after
resection usually occurs within 2cm of the tumor margin. Local delivery method such as …

Targeted therapies for cancer is a rapidly advancing field, but the identification of tumor-
specific ligands has proven difficult. Chlorotoxin (CTX) is a small, 36 amino acid neurotoxin …

A major impediment to the successful application of gene therapy for the treatment of a
range of diseases is not a paucity of therapeutic genes, but the lack of an efficient non‐toxic …

Malignant glioma is a devastating brain tumor with no effective treatment. This randomised,
controlled study involved 36 patients with operable primary or recurrent malignant glioma …

Over the past few years, technological procedures have been developed for utilizing stem
cells in transplantation medicine. Human embryonic stem (ES) cells can produce an …