Platelet function testing is essential for the diagnosis of hemostasis disorders. While there
are many methods used to test platelet function for research purposes, standardization is …

Platelets and platelet microparticles (PMPs) play a key role in the pathophysiology of
vascular disorders such as coronary artery disease and stroke. In atherosclerosis, for …

Flow cytometry is increasingly used in the study of platelets in inherited and acquired
disorders of platelet number and function. However, wide variation exists in specific …

Systemic inflammation and oxidative burden in patients with type 2 diabetes mellitus (T2DM)
causes deleterious cardiovascular outcomes. We sought to investigate the clinical …

Inherited platelet disorders are important conditions that often manifest with bleeding. These
disorders have heterogeneous underlying pathologies. Some are syndromic disorders with …

Background Platelet count alone does not reliably predict bleeding risk, suggesting platelet
function is important to monitor in patients with thrombocytopenia. There is still an unmet …

Background Multiple myeloma (MM) is associated with a high prevalence of bleeding and
an increased risk of thrombo-embolism. MM patients have reduced platelet-and red blood …

Background Xanthohumol (XN), a bioactive flavonoid from Humulus lupulus with anti-
inflammatory properties, has potential benefits for patients with Crohn's disease (CD), a type …

In preclinical and clinical studies, it has been demonstrated that tumor-educated platelets
play a critical role in tumorigenesis, cancer development, and metastasis. Unlike the role of …

Platelets are small but very abundant blood cells that play a key role in hemostasis,
contributing to thrombus formation at sites of injury. The ability of platelets to perform this …