Melatonin receptor structure and signaling
HH Okamoto, E Cecon, O Nureki… - Journal of Pineal …, 2024 - Wiley Online Library
Abstract Melatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to
membrane receptors. Several receptor subtypes exist in different species, of which the …
membrane receptors. Several receptor subtypes exist in different species, of which the …
The location, physiology, pathology of hippocampus Melatonin MT2 receptor and MT2-selective modulators
Y Feng, X Jiang, W Liu, H Lu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Melatonin, a neurohormone secreted by the pineal gland and regulated by the
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …
[HTML][HTML] Translational approaches to influence sleep and arousal
Sleep disorders are widespread in society and are prevalent in military personnel and in
Veterans. Disturbances of sleep and arousal mechanisms are common in neuropsychiatric …
Veterans. Disturbances of sleep and arousal mechanisms are common in neuropsychiatric …
In silico drug discovery of melatonin receptor ligands with therapeutic potential
Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …
Free-energy simulations support a lipophilic binding route for melatonin receptors
The effects of the neurohormone melatonin are mediated by the activation of the GPCRs
MT1 and MT2 in a variety of tissues. Crystal structures suggest ligand access to the …
MT1 and MT2 in a variety of tissues. Crystal structures suggest ligand access to the …
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors
In crystal structures of melatonin MT 1 and MT 2 receptors, a lipophilic subpocket has been
characterized which accommodates the phenyl ring of the potent agonist 2-phenylmelatonin …
characterized which accommodates the phenyl ring of the potent agonist 2-phenylmelatonin …