UCHL1/PGP 9.5 (also known as UCHL1 and PGP 9.5) was first detected as a “brain-specific
protein” over 28 years ago. The protein is highly conserved and localized in neurones and …

Spermatogenesis, an elaborate and male-specific process in adult testes by which a number
of spermatozoa are produced constantly for male fertility, relies on spermatogonial stem …

This study was designed to isolate, characterize, and culture human spermatogonia. Using
immunohistochemistry on tubule sections, we localized GPR125 to the plasma membrane of …

Abstract Three-dimensional (3D) organoids can serve as an in vitro platform to study cell–
cell interactions, tissue development, and toxicology. Development of organoids with tissue …

In the human testis, beginning at≈ 2 months of age, gonocytes are replaced by adult dark
(Ad) and pale (Ap) spermatogonia that make up the spermatogonial stem cell (SSC) pool. In …

Background Germ cell transplantation results in fertile recipients and is the only available
approach to functionally investigate the spermatogonial stem cell biology in mammals and …

Background Spermatogenesis is an intricate developmental process during which
undifferentiated spermatogonia, containing spermatogonial stem cells (SSCs), undergo self …

Spermatogenesis, an elaborate and male-specific process in adult testes by which a number
of spermatozoa are produced constantly for male fertility, relies on spermatogonial stem …

The undifferentiated spermatogonial population consists of stem and progenitor germ cells
which function to provide the foundation for spermatogenesis. The stem cell component …

Improved therapies for cancer and other conditions have resulted in a growing population of
long-term survivors. Infertility is an unfortunate side effect of some cancer therapies that …