Biological processes are naturally regulated with high spatial and temporal control, as is
perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively …

The proper formation and function of neuronal networks is required for cognition and
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …

Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown
therapeutic potential in recent studies. However, the corresponding therapeutic components …

MicroRNAs are small noncoding RNAs that regulate gene expression at the
posttranscriptional level in a sequence-specific manner. After their discovery in 1993 …

MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that play important
roles in the development and functions of the brain. Extensive studies have revealed critical …

Adult hippocampal neurogenesis involves proliferation, survival, differentiation and
integration of newborn neurons into pre-existing neuronal networks. Although its functional …

Stem cells offer the basis for the promotion of robust new therapeutic approaches for a
variety of human disorders. There are still many limitations to be overcome before clinical …

Glutamatergic neurons of the mammalian cerebral cortex originate from radial glia (RG)
progenitors in the ventricular zone (VZ). During corticogenesis, neuroblasts migrate toward …

The mammalian neocortex underlies our perception of sensory information, performance of
motor activities, and higher-order cognition. During mammalian embryogenesis, radial glial …

In the developing cortex, projection neurons undergo multipolar-bipolar transition, radial-
directed migration, and maturation. The contribution of these developmental steps to the …