GPCRs in intracellular compartments: New targets for drug discovery
I Fasciani, M Carli, F Petragnano, F Colaianni, G Aloisi… - Biomolecules, 2022 - mdpi.com
The architecture of eukaryotic cells is defined by extensive membrane-delimited
compartments, which entails separate metabolic processes that would otherwise interfere …
compartments, which entails separate metabolic processes that would otherwise interfere …
Golgi complex: a signaling hub in cancer
D Spano, A Colanzi - Cells, 2022 - mdpi.com
The Golgi Complex is the central hub in the endomembrane system and serves not only as a
biosynthetic and processing center but also as a trafficking and sorting station for …
biosynthetic and processing center but also as a trafficking and sorting station for …
[HTML][HTML] Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
Diversity and specificity in location-based signaling outputs of neuronal GPCRs
GA Kumar, MA Puthenveedu - Current Opinion in Neurobiology, 2022 - Elsevier
The common mechanisms by which members of the G protein–coupled receptor (GPCR)
family respond to neurotransmitters in the brain have been well studied. However, it is …
family respond to neurotransmitters in the brain have been well studied. However, it is …
The succinate receptor SUCNR1 resides at the endoplasmic reticulum and relocates to the plasma membrane in hypoxic conditions
The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle
metabolite succinate. GPCR signaling depends on the surrounding environment and …
metabolite succinate. GPCR signaling depends on the surrounding environment and …
The ufmylation cascade controls COPII recruitment, anterograde transport, and sorting of nascent GPCRs at ER
Ufmylation is implicated in multiple cellular processes, but little is known about its functions
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …
Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction
X Xu, L Qiu, M Zhang, G Wu - Journal of Cell Science, 2024 - journals.biologists.com
ABSTRACT G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell
surface signaling proteins that share a common structural topology. When compared with …
surface signaling proteins that share a common structural topology. When compared with …
Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship
Y Zhu, Q Hui, Z Zhang, H Fu, Y Qin… - Journal of …, 2024 - Wiley Online Library
Synapses serve as the points of communication between neurons, consisting primarily of
three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane …
three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane …
The olfactory receptor OR51E2 activates ERK1/2 through the Golgi-localized Gβγ-PI3Kγ-ARF1 pathway in prostate cancer cells
The olfactory receptor OR51E2 is ectopically expressed in prostate tissues and regulates
prostate cancer progression, but its function and regulation in oncogenic mitogen-activate …
prostate cancer progression, but its function and regulation in oncogenic mitogen-activate …
Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein–coupled receptor signaling to MAPK
After activation of G protein–coupled receptors, G protein βγ dimers may translocate from the
plasma membrane to the Golgi apparatus (GA). We recently report that this translocation …
plasma membrane to the Golgi apparatus (GA). We recently report that this translocation …