The architecture of eukaryotic cells is defined by extensive membrane-delimited
compartments, which entails separate metabolic processes that would otherwise interfere …

The Golgi Complex is the central hub in the endomembrane system and serves not only as a
biosynthetic and processing center but also as a trafficking and sorting station for …

G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma
membrane signaling proteins. However, virtually nothing is known about their recruitment to …

The common mechanisms by which members of the G protein–coupled receptor (GPCR)
family respond to neurotransmitters in the brain have been well studied. However, it is …

The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle
metabolite succinate. GPCR signaling depends on the surrounding environment and …

Ufmylation is implicated in multiple cellular processes, but little is known about its functions
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …

ABSTRACT G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell
surface signaling proteins that share a common structural topology. When compared with …

Synapses serve as the points of communication between neurons, consisting primarily of
three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane …

The olfactory receptor OR51E2 is ectopically expressed in prostate tissues and regulates
prostate cancer progression, but its function and regulation in oncogenic mitogen-activate …

After activation of G protein–coupled receptors, G protein βγ dimers may translocate from the
plasma membrane to the Golgi apparatus (GA). We recently report that this translocation …